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While in the party of an erection that persists lengthier than 4 several hours, the affected individual must find speedy health-related support. If priapism is not really treated quickly, penile tissue destruction and permanent lack of potency may well final result [see WARNINGS AND PRECAUTIONS].

Nonetheless, there won't be any managed clinical information on the security or efficacy of VIAGRA in patients with sickle cell or similar anemias.

Possess a record of vision challenges connected to nerve harm to the retina because of lowered blood move

Sildenafil was unfavorable in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes As well as in vivo mouse micronucleus assays to detect clastogenicity.

It can be eliminated predominantly by hepatic metabolism (primarily CYP3A4) and is also transformed to an active metabolite with Attributes similar to the parent, sildenafil. Each sildenafil as well as the metabolite have terminal 50 % life of about four hours.

Signify sildenafil plasma concentrations measured once the administration of only one oral dose of a hundred mg to healthier male volunteers is depicted down below:

Get in touch with your physician should you encounter these Unwanted side effects and they are severe or bothersome. Your pharmacist might be able to suggest you on taking care of Uncomfortable side effects.

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People who have experienced a myocardial infarction, stroke, or everyday living-threatening arrhythmia in the previous 6 months;

Lots of of those situations were documented to arise in the course of or Soon immediately after sexual exercise, and a few were being noted to arise shortly right after the usage of VIAGRA devoid of sexual exercise. Other folks were being noted to possess happened hrs to days soon after using VIAGRA and sexual action. It really is impossible to determine whether or not these occasions are linked straight to VIAGRA, to sexual here activity, for the affected person's fundamental cardiovascular disease, to a combination of these aspects, or to other factors [see WARNINGS AND PRECAUTIONS and Individual Info].

In reports with healthy volunteers of solitary doses as much as 800 mg, adverse reactions had been much like All those found at reduce doses but incidence charges and severities had been improved.

In the event your health care provider has recommended a dose different from those detailed right here, tend not to alter the way you are getting the medication without having consulting your physician.

There are postmarketing reports of bleeding situations in clients which have taken VIAGRA. A causal connection amongst VIAGRA and these events hasn't been set up. In humans, VIAGRA has no impact on bleeding time when taken by itself or with aspirin.

Although unusual, some individuals have documented everlasting vision decline. Stop taking sildenafil and get help immediately For those who have sudden eyesight reduction in one or each eyes.